From I-75 Take Exit 141; turn west onto Palm Beach Blvd./SR 80 and move into center lane, continuing for 5 miles until you get to Fowler. Drive straight across Fowler and move into left lane to enter the River District on First Street.
From Edison & Ford Winter Estates/McGregor Blvd. Exit left from rear parking lot onto Marlyn Rd., left onto Larchmont Ave., then east (right) onto McGregor. Continue east on McGregor in the left lane. At the U.S. 41 intersection stay in left lane; it will veer left onto Main Street. Drive Main Street 4 blocks to Hendry Street; turn north (left) 1 block to First Street.
From Dr. Martin Luther King, Jr. Blvd./ SR 82 Westbound/Exit 138 on I-75 Drive west on Dr. MLK Jr. Blvd. to Hendry Street stoplight; turn north (right) onto Hendry. Continue straight 3 blocks to First Street to enter the River District.
From U.S. 41/Cleveland Ave. Northbound Keep in right lane. After Victoria Avenue, follow brown Historic District sign/exit ramp, keeping to left side of exit ramp. Lane will veer right onto Main Street. Drive Main Street 4 blocks to Hendry Street; turn north (left) 1 block to First Street.
From U.S. 41/Cleveland Ave./ Caloosahatchee Bridge Southbound Keep in right lane. Immediately after crossing Caloosahatchee River, take first exit (marked 80/82 Downtown), looping right onto First Street east. Continue straight under bridge and for 4 more blocks.
From Business U.S. 41 /Fowler St./ Edison Bridge Southbound Keep in right lane. Take first available right exit at Edwards Drive, driving west and turning south (left) onto Hendry Street. If you miss that exit, simply continue south on Fowler to First Street stoplight and turn west (right).